Exact(2)
A positive shift in Tm indicates stabilization of the protein by an increase in structural order and a reduction in conformational flexibility, while a negative shift in Tm indicates destabilization.
In contrast to the residues that interact with Ca2+at the catalytic domain, Ca2+ in the noncatalytic domain has higher values of RMSd and RMSf, which indicates destabilization and flexibility of the residue.
Similar(58)
Proteolysis measurements on thousands of tethered collagen molecules show a load-enhanced trypsin sensitivity, indicating destabilization of the triple helix.
The two largest shifts in midpoints E1392C (rightward) and F1385C (leftward) relative to WT indicate destabilization and stabilization of the inactivated state relative to non-inactivated states, respectively.
On the other hand, MIF transcript levels were not impaired, indicating destabilization of MIF protein on HER2 inhibition.
Formation of the LG-histone adduct is associated with an increased histone solubility in NaCl, indicating destabilization of the nucleosome structure; this is also reversed with scavenger treatment.
On the other hand, for liquid heating μ* < 1, the neutral stability curves shift to lower Rayleigh numbers and higher wave numbers, indicating a destabilization of the flow, whereas for gas heating μ* > 1, the opposite trend is true. Figure 4 Neutral stability curves for selected values of μ *. Figure 5 Neutral stability curves for selected values of ξ.
The obtained values indicate a destabilization of the hydride compared to typical bulk enthalpies.
In parallel we showed that the ratio of angiopoietin-1/angiopoietin-2 wasignificantlyly reduced indicating vessel destabilization.
Taken together, these results indicate that destabilization surgery induces OA activity as early as 2 weeks after surgery, and is accelerated by FM during early OA development.
The ability to compare miRNA, mRNA, and protein expression in the identical samples defined a comprehensive miRNA regulatory network that indicated RNA destabilization, translational repression and activation.
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