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The area marked "bundle cost-saving" on each graph indicates combinations of cost and effectiveness at which the bundle reduces total costs and delivers extra health benefits relative to the comparator.
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The total count of exons indicates combination diversity.
As you say, there are already studies indicating combinations should be evaluated in this fashion.
Uptake of [18F]FPyPEGCBT-c RGDfK) was also evaluated after 1 h of incubation with cells with selective siRNA-mediated knocked down of αV, β1, β3 or β5 integrin subunits and indicated combinations (c).
U-87 MG and SKOV-3 cells knocked down for αV, β1, β3 or β5 integrin subunits and indicated combinations were incubated with 100 kBq/mL [18F]FPyPEGCBT-c RGDfK) for 15 to 120 min at 37 °C.
αV, β1, β3 or β5 integrin subunits and indicated combinations were knocked-down by siRNA in U-87 MG and SKOV-3 and protein extracts were submitted to immunoblotting using specific antibodies.
Positive Z values indicate combinations where were local antagonists show higher spore load than foreign antagonists.
Positive Z values indicate combinations where local antagonists show higher mortality than foreign antagonists.
For size-exclusion chromatography, indicated combinations of purified protein (100 picomoles each) were pre-incubated at a concentration of 1.1 μM for 10 min at 4°C.
The indicated combinations of double transformants were plated in media lacking Leu, Trp, Met and His (−HIS),−HIS with 3-AT (1 mM or 5 mM) or Leu, Trp and Met (+HIS).
Analysis of relaxation modulus and creep compliance mastercurves indicated combination of SBS and HDPEHP offered higher resistance under creep load and strain under long term conditions.
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