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The increased release of pro-inflammatory cytokines by DC indicates augmented CD4+ and CD8+ T-cell activation.
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These data indicate augmented food metabolism towards higher ratio of carbohydrate utilization.
These results indicated augmented LC3-II synthesis in the oxidatively stress cultures.
Differences in PPTs between individuals at sites distant to tissue injury may indicate augmented central pain processing [ 2].
One study found DKK1 to be preferentially expressed in hormone receptor-negative cancers; as DKK is a Wnt target gene, however, this elevation may actually indicate augmented pathway activity [ 126].
In light of the microcirculatory effects of colloid administration in the present study, intestinal tissue oxygen pressure as well as mesenteric metabolic markers indicate augmented oxygen supply and sufficient cellular substrate.
Nonetheless, as Tfr cells are negative regulators of GC reactions (Ramiscal and Vinuesa, 2013), their abundance may indicate augmented suppression of Tfh cells and long-term B cell responses.
Similarly, widespread reductions in PPTs in people with OA [ 14] or FM [ 26] have been taken to indicate augmented central pain processing, and sensitivity to pressure has been associated with increased activity in several brain regions during functional MRI studies [ 29, 30].
Noninflammatory pain mechanisms in RA may share some common characteristics with those found in other arthropathies, such as osteoarthritis (OA), in which greater sensitivity to pain at nonjoint sites, as well as at sites affected by arthritis, may indicate augmented central pain processing [ 2].
These data indicate that augmented NRP2 expression is caused by canonical TGF-β/Smad signaling.
Importantly, patients who manifested ARC on day 1 were significantly more likely to do so on subsequent measures, indicating that augmented drug CL is unlikely to be short-lived.
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