The genetic correlations between FP, VP and FF were all significant and moderate to large in size (0.44 0.65), indicating a substantial proportion of the genes influencing each phenotype are the same.
According to the 2005 National Family Health Survey, around 14% of the households in Kolkata were poor, while 33% lived in slums, indicating a substantial proportion of households in slum areas were better off economically than the bottom quarter of urban households in terms of wealth status.
In silico analyses indicate a substantial proportion of these mutations are potentially deleterious.
4 Despite the availability of multiple treatment options, recent studies indicate a substantial proportion of US women at risk of fracture remain untreated.
The AFs were considerable for the younger and middle aged groups, indicating a substantial proportion of smoking in both countries that would be prevented if the low educated did smoke at a similar rate as the high educated.
On top of these difficulties, most clinical studies indicate that a great proportion of patients, even if treated with the most potent available agents, will not successfully control their glycemia to the degree recommended by guidelines (e.g., achieving an A1C value ≤7.0%), indicating a substantial proportion of "nonresponders" to almost all available treatments (10– 10).
Indeed, in the overall study population, 56% of patients either had a CD4 T-cell count ≤200 cells/μL (37%), or CD4 T-cell count ≥201 to 350 cells/μL with HIV-1 RNA ≥ 100,000 copies/mL (Table 2), indicating a substantial proportion of individuals with more advanced disease and/or a more compelling need to initiate therapy, as per treatment guidelines.
The combined frequency of TSC1/TSC2 mutations of 15% indicates that a substantial proportion of UC tumors may show activation of mTOR through TSC1 or TSC2 mutational inactivation.
However, only a subset of patients initially respond to these inhibitors, and increasing clinical evidence indicates that a substantial proportion of initial responders ultimately relapse with lethal, drug-resistant disease months or years later.
