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This indicates a substantial effect on subsequent steps in the catalytic cycle, which is supported by the fact that kobs for E287D and E287Q are closer in value than are their respective kcat values.
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Together, these results indicate a substantial effect on gene expression in adult male D. melanogaster resulting from X-chromosome and Y-chromosome parent-of-origin.
These data indicate a substantial effect of tamoxifen but it is clear that approximately half of patients are resistant to tamoxifen de novo (early relapses) or acquire resistance if we assume that women who relapsed later had an initial response to tamoxifen.
Protein changes after oral ET in postmenopausal women observed in this study indicate a substantial effect on coagulation and metabolic proteins that may explain the increased risk of venous thromboembolism and stroke and the reduced risk of fracture found in the WHI trial.
Previous work shows that left ventricular elastance and pressure volume relationships in master's athletes are similar to those of young controls, indicating a substantial effect of life-long training on ventricular and arterial compliance (Arbab-Zadeh et al. 2004; Shibata et al. 2008).
The size of the meta-effect indicates a substantial clinically meaningful change (>0.10 m/s).
These results indicate a substantial genetic effect and suggest major gene effects for the trait.
A successful outcome after lumbar discectomy indicates a substantial improvement.
This indicates a substantial improvement in the codification.
This clearly indicates a substantial demand-supply gap.
All estimates indicate a substantial sanction effect, further supporting the validity of the chosen instruments.
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