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LV indicates a sample of likely voters.
The vast majority of studies had small sample sizes (range 36 250), with only one with a reasonable sample size n=410 (sample size calculated on the CSR meta-analysis outlined below indicates a sample of >700 is required); quality of the studies is highly varied, with concerns mostly regarding allocation sequence generation and allocation concealment, which this proposed study addresses.
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A power larger than 0,9 at α = 0.05 indicated a sample of proper size.
The mean length of injecting career was 20.9 years indicating a sample of chronic injecting drug users, of whom only one-third (38%) were born in Delhi.
The majority of the participants were in the 25 34 year age range indicating a sample of young adults as would be expected among parents of preschool age children.
Mean infarct volume was 19±53 mL and National Institute of Health Stroke Scale (NIHSS) at Time 1 (within 12 days of stroke) was 4±4, indicating a sample of mild strokes.
This estimate did not include dropout rates, which was 10% for falls data in our study, indicating a sample of 363 participants.
Based on the data in our systematic review, a sample size calculation using α = 0.05 and 1 – β = 0.80 indicates a sample size of 265 patients per arm, without dropout correction.
Power calculations indicated a sample size of 12 for each group was needed resulting in the subset of 54 (Moormann, manuscript in preparation).
Our power calculations indicate a sample size of 112 is required for both primary outcomes.
These parameters indicated a sample size of approximately 15 per group.
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