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Moreover, the increase in osteocalcin levels on IGF-1 administration indicates a role of IGF-1 on osteocalcin regulation as reported by Johansson et al. [38].
Moreover, the dramatic and early up-regulation of Bf/C2-A in skin indicates a role of this molecule as an acute-phase reactant.
On the other hand, increasing evidence indicates a role of Axin in nucleus (Nikuseva Martic et al., 2010; Pecina-Slaus et al., 2011; Schmitz et al., 2013; Willert and Jones, 2006).
A similar immune response was found in serum of patients, which indicates a role of this response in the pathogenesis of ARF.
The expression of IL-2 by NSPCs possibly indicates a role of these cells in modulating the proliferation of T-cells.
The finding that caveolin-1 KO livers show reduced levels of both PDE3B activity and protein expression indicates a role of caveolin-1/caveolae in the stabilization of the PDE3B protein which has also been demonstrated for the adipocyte PDE3B [5].
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These findings indicate a role of IL-25 in breast tumor development.
These studies indicate a role of inflammasomes in immunosuppression during tumorigenesis and metastasis.
The studies of the effect of diluents clearly indicate a role of diluent in extraction of uranium from aqueous solutions.
Subsequent experiments indicated a role of fumarase insufficiency in the development of hypertension in SS rats.
In vivo studies indicate a role of IGF-I and IGF-IR in breast cancer development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com