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This indicates a positive feedback model where MYC can reinforce its own expression from the PVT1 promoter in PVT1-MYC fusion tumours.
This indicates a positive feedback for infection in these high prevalence herds and the possibility that two states may arise, herds with a stable low seroprevalence and herds with a stable high seroprevalence with different within herd dynamics.
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Our work may indicate a positive feedback operating in the fMAPK pathway.
We found that PGE2 could induce expression of PTGER4, indicating a positive feedback system induced by the PTGS-PGE2 synthase-PGE2 pathway to maintain PTGER4 expression.
Indeed, LEF1 is a direct transcriptional target of the LEF1/β-catenin complex[23], indicating a positive feedback loop for Wnt signaling, and suggesting LEF1 might be useful as a prognostic biomarker of Wnt pathway activation.
In this study, we show that Atf1/Pcr1 bind at the promoter of both atf1+ and pcr1+ genes (Figure 3), indicating a positive feedback loop in transcriptional regulation of atf1+ and pcr1+ that has been hypothesized by others [14].
Increased TLR9 expression correlates with increased responsiveness to the ligand, indicating a positive feedback loop in which CpG2006 enhances its own effects [ 29].
Evidence for bidirectional causality was present as well, with changes in relaxation predicting changes in energy and vice versa, indicating a positive feedback loop.
BMPs and noggin reciprocally induce their expression in osteoblasts [23], indicating that a positive feedback is necessary for maintaining an optimal balance between BMP and noggin concentrations in the bone microenvironment.
Furthermore, our findings indicate that a positive feedback loop exists in which IL-23 can enhance its own production via the induction of IFN-γ and GM-CSF, which both prime monocytes for enhanced IL-23 production.
These results indicated that a positive feedback loop exists between E-cadherin and the EPHA2 receptor.
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