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As this property is less important for antimicrobial activity, it was suggested that it indicates a constraint for the peptide to traverse mammalian membranes (Gifford et al., 2005).
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This indicates a dimensional constraint in the 2 nm thick film.
It is probable that the restriction of round-snouted, selectively browsing dicraeosaurids to this type of environment in the Morrison Formation indicates a similar constraint on sauropod dinosaurs.
Moreover, the associated dN/dS ratios with the retrocopies tended to decrease as dS increased (Fig. 3), which indicates a greater constraint of selection on older retrocopies.
"We have tier one module makers and equipment makers call us looking for inventory," says Meyers, and that indicates a serious supply constraint.
An exception to this trend was the ribosomal protein gene rpl2, whose Ka/Ks ratio indicates a relaxed selective constraint in combination with moderate sequence divergence.
They recorded SNP density in a pri-miRNA region at 3 SNPs per kb and only 1.3 SNPs per kb in a pre-miRNA region, which indicates a strong selective constraint on human pre-miRNAs (28).
Ratios below 1 indicate a selective constraint at that position, favoring specific AAs [ 25].
Sites with that many substitutions are rare, indicating a widespread constraint on the rate of evolution.
Introns are generally neutral to selection and undergo rapid change during evolution [ 49], therefore high sequence similarity between orthologous introns indicate a functional constraint during evolution [ 52].
As the DH and KR domains are functionally redundant within the LM, this does not indicate a functional constraint imposed on this pairing, but does suggest that the AT-III and DH domains 'move' as a group.
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