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In addition, this study demonstrates that the adhesion- and growth-enhancing effects of apoE4 substrates are not mediated by heparan sulfate proteoglycans (HSPGs), proteins that have been indicated to function as receptors or co-receptors for apoE4.
In addition, Yap5 has been indicated to function as an iron-responsive transcriptional activator that regulates vacuolar iron storage (Li et al., 2008).
Cyclin D1 is indicated to function as a positive regulator of G1 progression by inactivation of pRb and E2F1.
Conclusively, the LINC complex is indicated to function as a communicator between spermatid chromatin and the acroplaxome by which signals nucleosome remodelling could be initiated.
CDK8 has been indicated to function as an oncoprotein that promotes the proliferation of both colorectal and melanoma cancer cells (Firestein et al, 2008; Kapoor et al, 2010).
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Furthermore, the specificity of the inhibitors is often not very high, and this is clearly illustrated by the fact that one of the most potent inhibitor of bone resorption and acid secretion, Rottlerin, has been indicated to exert a function as a proton-ionophore [ 63], which thus would explain its highly potent effect in all the assays.
The developed glucose-sensitive gels responded to varied glucose concentrations in vitro indicating their ability to function as environment-sensitive systems.
It is important to recognise that most mutations affecting splicing factors such as SF3B1, U2AF1, and SRSF2 are more likely to cause gain of functions, 9, 33) indicating that they are unlikely to function as tumor suppressors.
In T. annulata, experimental evidence indicates that they are likely to function as modulators of host cell phenotype, possibly in concert with activated host cell transcription factors [ 13, 16].
International normalized ratio was 1.25 indicating deteriorating liver function as well.
The betalain extract shows a broad absorption spectrum in the visible light region (ca. 400 700 nm) indicating that betalain has the ability to function as an efficient sensitizer for wide bandgap semiconductors [40, 41].
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