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Recent results with monoclonal antibodies directed against beta-amyloid have indicated that efficacy may be greater when such agents are applied early in the disease process.
8 However, the SUSTAIN ii and IVAN iii studies indicated that efficacy outcomes could be achieved with less than monthly dosing.
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Our current data appears to confirm the efficacy of NV-01 and indicates that efficacy lasts for at least 28 days following a single injection.
This result indicates that efficacy of the released DOX is effectively fast.
In AD, several preclinical studies have shown the short-term benefit of stem cell transplantation in murine models and indicate that efficacy is frequently associated with the delivery of neurotrophic factors14,15,16,17,18,19,20.
In another prospective study, patients changed their preferences favoring a nasal formulation of zolmitriptan because of the speed of onset and the overall efficacy compared to conventional zolmitritpan tablets [14], again indicating that efficacy matters most for the symptomatic treatment.
This result indicates that efficacy of maturation is cell type dependent.
Results from several large studies also indicate that efficacy may decline following cycling to a second TNF inhibitor [ 25- 30].
Recent clinical studies indicate that efficacy of artesunate mefloquine combination is decreasing on both sides of the border (1 – 3 ).
Recent positive clinical trials with anti-CGRP monoclonal antibodies for chronic or frequent episodic migraine indicate that efficacy can be achieved via actions at the periphery alone.
These observations clearly indicate that efficacy against mycobacterial replication is significantly enhanced when nanoformulations of the two frontline drugs are used in combination.
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