Noticeably, 5 labels both diffuse and fibrillar plaques in brain sections of AD patients, while lacking interaction with biomarker proteins of other neurodegenerative diseases thereby indicating specificity for detecting Aβ in AD.
Importantly, [18F]-9 lAβels Aβ plaques in cortex of autopsy confirmed AD brain sections, while also demonstrating a close immunohistochemical correlation with anti Aβ antibody-conjugate thereby indicating specificity for mapping the biomarker protein.
The constitutively active SV40 promoter, by contrast, was not activated by vRNAs, indicating specificity for the IFN system.
Addition of catalase, 500 units/ml, reduced fluorescence to below the detectable limit indicating specificity for H2O2.
The known bioactives Reactive Blue 2, 6-hydroxy-DL-DOPA and myricetin were subsequently demonstrated to enhance the cytotoxic and genotoxic potential of the alkylating agent MMS in cell culture assays, indicating specificity for APE1 and exemplifying their prospect as biological probes for APE1 function.
EMSA revealed that incubation of the DNA protein complexes with anti-Sp1 or anti-p65 antibodies shifted the migrating bands in an upward direction, indicating specificity for Sp1 and NF-κB (p65) proteins (Fig. 6A, 6B, 6C and 6D, lane 4).
No significant SptP-dependent changes in global cellular phosphotyrosine levels were observed, indicating specificity for VCP.
Mitochondrial PKCδ translocation was unaffected by ψεHSP90 treatment, indicating specificity for PKCε.
Notably, combinations of isw1Δ with Swi/Snf mutations did not confer suppression, indicating specificity for suppressing RSC function.
