The ratio IC50 in the guinea-pig ileum/IC50 in the mouse vas deferens, indicating selectivity for δ-opioid receptors, was high for Cys(O2NH2 2-containing analO2NH2 2-containingly for [Cys(O2NH2)2, Leu5]enkephanaloguesch wandabout sespecially more selective than δ-opioid receptor selective ligand cyclic [d-Pen2, d-Pen5]enkephalin (DPDPE).
No inhibition by PDAT was observed at 2 mM when it was tested against structurally similar Class 1 methyltransferases, such as human phenylethanolamine- N-methyltransferase (hPNMT) and human nicotinamide- N-methyltransferase (hNNMT), indicating selectivity for INMT.
A comparison of the single agent treatments and the combination treatments for mitoxantrone indicated selectivity of the drug at lower concentrations.
These proteases, which were confirmed as being active with positive control substrates, were also unable to convert HP-1 to DHP-1, further indicating selectivity of HP-1 for a subset of Class I HDAC enzymes (Table 1).
EC50 values against PPARα and PPARγ were found to be 5680 n m and 243 n m for muraglitazar and 4780 n m and 3420 n m for tesaglitazar, respectively, indicating selectivity towards PPARγ activation, particularly for muraglitazar.
A difference arises from the existence of additional 24- to 26-mers in the library of Ruby and co-workers indicating selectivity in the cloning method for these specific lengths of small RNA molecules.
Moreover, the selectivity of the scAb-based biosensor was tested using a kallikrein 2 protein, a protein structurally similar to PSA, and the results indicated high selectivity for PSA detection.
In vitro data in unstimulated bovine aortic coronary endothelial cells indicated the selectivity for Cox-2 by ACE more than Cox-1 [ 18].
The identification of Cnidarian Na+-selective ion channels distinct from the channels of bilaterian animals indicates that selectivity for Na+ in neuronal signaling emerged independently in these two animal lineages.
However, they were unable to reverse ABCB1- or ABCC1-mediated MDR indicating their selectivity for ABCG2.
