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With the mental and physical effects of workplace stress and overwork so clearly known now – depression, anxiety, reduced immunity, higher blood pressure, digestion problems, headaches, muscular problems, substance abuse – it is, as the Cigna wellbeing report indicated, essential for employers to wake up to what they are losing in their workforces by allowing this situation to keep getting worse.
Additionally, the presence of autoantibody-producing B cells has been indicated essential for the efficacy of RTX treatment [ 50, 51].
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10.7554/eLife.04193.006 Figure 3. Expression of the dominant negative FGF14ΔNT affects multiple NaV channel biophysical properties indicating essential roles for the FGF14 N-terminus.
Pre-treatment with inhibitors of the ERK pathway (PD98059) or phosphoinositide 3-kinase (PI3K /Akt pathway (LY294002) fully prevented insulin-induced migration (Fig. 4b), indicating essential roles for these signalling pathways.
Vertical arrows indicate essential amino acid residues for catalytic activity of fungal chitosanases.
As this region has been indicated as essential for the myotoxic mechanism, the ligands could potentially be used as inhibitors for BnSP-7.
Effective D1 turnover has been indicated as essential for the recovery process from photoinhibition [ 42].
Detailed mapping of the structural elements present in Eps15 that are required for ubiquitination indicated an essential role for the UIM motifs [ 59, 60].
These results indicated an essential role for miR-320 in maintaining erythrocyte homeostasis during terminal differentiation in normal reticulocytes.
First, findings in both humans and mice have indicated an essential role for this cytokine in co-stimulating B cells to differentiate into plasma cells [ 29].
We have indicated the essential role for knowledge synthesis in all phases of TR by placing it at the center of Figure 1.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com