Although a decrease in fresh weight can indicate cold stress, water loss is not always an accurate indicator of cold stress, because plant variety, leaf area, and other stressors can also affect water content measurements.
The solid stars indicate cold seep sites at the Oomine Ridge; open star indicates cold seep sites at the other area.
During the late glacial Pinus forest developed around the lake, indicating cold and dry conditions.
During Larevka time span vegetation and fauna indicate cold climate conditions.
Freshwater and terrestrial molluscs were represented by rare widespread species while the ostracoda species indicate cold conditions.
Finally, the maximum extreme temperature-related mortality risk among all lag periods was used to indicate cold and heat effects the significant mortality increases associated with cold stress and heat stress respectively.
A comparison of pollen data and magnetic susceptibility suggests that magnetic susceptibility is a reliable proxy for climate changes, with a high magnetic susceptibility value reflecting warm climate conditions and a low magnetic susceptibility value indicating cold periods.
Thresholds for cold and heat pain were significantly decreased, indicating cold and heat hyperalgesia (HPT: 0.60±1.50; CPT: 1.01±1.23; both p<0.001).
In our study, the Z-score of the cold pain threshold in 1911GG carriers was lower than in AG and AA carriers (−0.13±1.10 vs. 0.19±1.20 and 0.18±1.14 respectively) indicating cold hypoalgesia.
In the cold, the network analysis revealed the three amino acids remain correlated in L/L at 4°C (Figure S1) but are no longer circadian regulated, further indicating cold disrupts circadian regulation of metabolism.
