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Because changes in gene transcription, indicated by altered levels of mRNA encoding specific peptides or proteins, are physiologically relevant markers of cellular activity, the ability to perceive these changes and to determine their magnitude accurately is of great importance.
Furthermore, lack of α9 receptor subunit expression may result in perturbed ionic homeostasis in adult cochlear hair cells, as indicated by altered expression of numerous voltage-gated ion channels.
Loss of peripheral heterochromatin is known to occur in RD and MADA cells, as indicated by altered histone methylation patterns and electron microscopy analysis [ 9, 19, 36].
This is indicated by altered expression of an auxin-responsive reporter protein and by reduced abundance of PIN auxin transport proteins.
Contractile activity of skeletal muscle may lead to oxidation of many biomolecules, indicated by altered muscle and blood glutathione levels and an increase in protein, DNA, and lipid oxidation (41, 47).
Jump-in of the P-element at a new position was indicated by altered red eye colour in comparison to the red eye colour of the original P EPgy2) EY02323 insertion.
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However, caution should be exercised when using this extract as was indicated by the altered parameters.
Caution should be exercised when using this natural product extract as was indicated by the altered biochemical parameters; AST, urea and creatinine.
We therefore co-infected SAOS-2 cells with adenovirus expressing RB and Cdk2/Cyclin E. As would be expected, co-expression of RB with Cdk2/Cyclin E led to RB phosphorylation, indicated by the altered electrophoresis mobility in SDS-PAGE (Fig. 5A).
The initial clinical syndrome was classified as WNV encephalitis, indicated by fever and altered mental status or other cortical signs (e.g., seizures) and cerebrospinal fluid (CSF) suggestive of viral infection; WNV meningitis, indicated by fever, meningeal signs (documentation of Kernig sign, Brudzinski sign, or nuchal rigidity), and CSF suggestive of viral infection; or WNV fever with headache.
By disrupting the activity of specific phenazine genes in wildtype PA01 the ratio of production of the various phenazine molecules is altered as indicated by the change in bacterial cell free supernatant color (Fig. 2B).
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