Nevertheless, benzodiazepines continue to be prescribed for the long-term treatment of anxiety disorders, although specific antidepressants and psychological therapies are recommended as the first-line treatment options with the anticonvulsant drug pregabalin indicated as a second- or third-line treatment and suitable for long-term use.
DPP-4 inhibitors are indicated as a second- or third-line therapy in combination with other oral antidiabetic drugs according to treatment guidelines in different parts of the world (23, 24).
Denosumab is indicated as a second-choice drug in the secondary prevention of refractures, and can be prescribed in the presence of contraindication or proven side effects of and further fractures under the approved first-choice treatment.
This technique in indicated as a first-choice treatment option for severe cases or those having had surgery but with significant residual deformities present.
Paclitaxel is an antineoplastic agent indicated as a first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary and other various cancers including breast cancer [24].
Therefore, splenectomy is generally indicated as a second-line treatment option for those patients failing first-line therapy.
In conclusion, after operative treatment of any type of endometriosis, COH-IUI is indicated as a second-line treatment even in cases of advanced maternal age.
Incorporation of taxanes as first-line treatment for advanced urothelíal carcinoma may not only offer an alternative to gemcitabine/cisplatin but may eventually be indicated as a first-line treatment, if equivalence to M-VAC or gemcitabine/cisplatin regimens can be confirmed by further studies.
First indicated as a valid stimulation area for the treatment of depressive states [16, 17], recently the DLPFC has also been considered a potential target for nociceptive control [18].
The questionnaire consists of 13 analysis forms: the first 4 (indicated as A, B, C and D) refer to the essential structural and functional prerequisites for efficient adoption of the tools of CG, the other 9 (numbered as 1, 2, 3, 4, 5, 6, 7, 8 and 9) investigate the single CG areas and are aimed at the evaluation of the effective application level of each tool.
