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The high level of cleaved caspase-3 during the entire recovery time, even when the level of active caspase-9 was negligible, indicated activation of other caspases, such as caspase-8 and, to a lesser extent, caspase-12.
This result is consistent with the previous meta-analysis of neuroimaging literature that indicated activation in these two areas was most frequently reported in studies that involved explicit perceptual and motor timing tasks11.
Comprehensive phenotypic network and pathway analysis results, which were based on genomic expression data, indicated activation of differentiation related mechanisms, via signaling pathways, including TGF, BMP, and vascular endothelial growth factor.
Both MMP-1 and MMP-13 were observed in both groups, and in mild TMJ-ID SF the low molecular weight forms of MMP-1 indicated activation of the enzyme.
The in vivo release kinetics of prodrug in rat clearly indicated activation of prodrug to be occurring in blood, being catalyzed by the weak alkaline pH of blood (7.4) in combination with esterases present therein.
Direct comparison of functional MRI signals obtained during 3∶2 or 2∶3 and on-the-beat rhythms indicated activation differences bilaterally in the supplementary motor area, ipsilaterally in the supramarginal gyrus and caudate-putamen and contralaterally in the cerebellum.
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In addition, exposure to DHEA results in decreased resistance to lysis by Triton X-100 and lysozyme, indicating activation of murien hydrolase activity.
This supports a functional relationship between HDAC activity and RelA/p65 expression and nuclear translocation (indicating activation).
The amber and dark blue boxes indicate activation and repression of transcription by direct association of OmpR, respectively.
As demonstrated in Fig. 1, soluble EA1-Fc treatment caused down-regulation of EphA2 and elevation of phosphorylation level of tyrosine, which both indicate activation of EphA2 kinase.
A time-dependent increase in phosphorylation of ASK1 at T845, indicating activation of this enzyme, was observed.
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