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(ORi = OReg/OReORg, ORi > 1 indicated a positive interaction (synergy); ORi < 1 indicated a negative interaction (antagonism); ORi = 1 indicated that there was no interaction).
Only TSA treatment correlated significantly with increased H3K4me3 (p < 0.01, Figure 4B), consistent with previous studies that have indicated a negative interaction between de-acetylation at lysine 9 by HDAC activity and trimethylation at lysine 4 (Lee at al., 2006b).
Similar(58)
For the lowest inflow rate, the reduction in soil loss by interaction between rainfall and inflow accounted for 20% of total soil loss, indicating a negative interaction.
Similar expression profiles indicate a positive interaction and dissimilar profiles indicates a negative interaction.
Then, the edges (that is, connections) correspond to a strongly significant interaction between nodes and red edges indicate a negative interaction between two nodes.
The value of S < 1 indicates a negative interaction which is in agreement with what is indicated by RERI = −2.18 < 0 and AP = −0.76 < 0.
Our previous studies also indicate a negative interaction between D1-like and insulin receptors because a D1-like receptor agonist, fenoldopam, inhibits the proliferative effect of insulin in A10 cells [ 13].
In contrast, the triple mutant (S83F-D87G-S80I) contributed 1% less offspring per generation than the parent strain: this indicates a negative interaction between these mutations, with the third mutation wiping out the fitness advantage of the double mutants.
Given that genetic interaction experiments also indicated a negative regulatory function of RSK in the neuromuscular system (Fischer et al., 2009b), we investigated whether RSK and ERK colocalize in motoneurons and whether loss of RSK has an impact on ERK activity or its subcellular localization.
The peak position was slightly shifted to the Hu < 0 region, which also indicates a negative mean interaction field (Roberts et al., 2000).
The observed nH values are lower than unity (∼0.5) (see Table 2), indicating a negative cooperative interaction between imipramine and each mecamylamine isomer.
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