Together, these results indicate a complex role for c-Jun in cellular responses to CCI-779 and provide an important basis for investigating CCI-779 further as a potential therapeutic agent for pancreatic tumors.
Whether these data can be reconciled by accounting for procedural differences or indicate a complex role for BK during the day remains to be determined.
TNF-α is central to regulation of many inflammatory pathways, and treatment with TNF-α inhibitors can cause lupus flares or lupus-like symptoms, possibly through upregulation of IFN-α [ 40], indicating a complex role for this cytokine in SLE.
Nevertheless, the kinetics of these events appeared to be modified in Hut-shLAT cells, indicating a complex regulatory role of LAT on TCR signaling.
Research indicates that religiosity plays a complex role in mental illness.
There is no unifying expression pattern for plant genes containing putative CCAAT promoter elements, indicating that they may play a complex role in regulating plant gene transcription [ 32].
However, recent observations indicate a more complex role of both receptors in cardiovascular pathologies, which still need to be further elucidated [10].
The recent data generated in experimental models indicate a more complex role of IFN-γ in the pathogenesis of Th1-mediated autoimmune diseases than originally proposed.
Other putative targets have been identified in separate clusters and intriguingly some genes downstream of GAAATT-abundant promoters have been shown to be repressed by CBP60g and SARD1, indicating a potentially complex role in the control of defence gene expression responses.
Complement activation has, on the other hand, been considered to have tumor suppressive properties, and C1q can induce apoptosis in prostate cancer cells [ 44, 45], indicating a complex and probably context-dependent role of C1Q in tumor development.
