Pretreatment of TRPV1 activator capsaisin (10 μM) brought the same effect as the culture medium with the pH 5.0 did, which indicated a central role of TRPV1 in the impaired epithelial function induced by acidic stress.
Amongst those, Mis16/Mis18 complex is required to maintain histone acetylation status at the central-centromere region, indicating that it has a central function in modifying centromeric chromatin (Hayashi et al, 2004).
However, our results and those of others (Mochizuki-Kashio et al., 2011) indicate that Ezh2 does not have a central function in controlling angiogenesis during embryonic development.
It indicates that miRNAs are essential regulatory elements for mechanisms that ensure correct axon guidance decisions at the midline and thus have a central function in the establishment of circuitry during the development of the nervous system.
Normally, a central function of adenosine is to inhibit the release of various chemicals into the brain, lowering energy levels and promoting sleep, among other regulatory bodily functions.
Authors suggest that the latter finding involves central pain processing, indicating a central "neuropathy-like" component contributing to symptom generation.
This result is in agreement with data from constant illumination and on cellulose [ 14], which indicates the central function of GNB1 to be carbon source independent.
The only putative motif of the deduced protein of EED1, which may indicate a cellular function, is a central glutamine-rich region similar to the S. cerevisiae protein Def1 [29], [30], [30], which may facilitate interactions with other proteins.
