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This experimentation could indicate the essentiality of these motifs for the formation of the transporter pore and the interaction with the substrates.
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These results indicate that the essentiality of a given gene or protein does not depend only on its multifunctionality, perhaps there are some other parameters which influence the gene/protein essentiality.
This analysis indicated that the essentiality of B was highly specific to cell lines harbouring gene A deficiency, and hence B is synthetic lethal in the context of deficiencies in DDR genes.
These results show the essentiality of nutrient sensing for mTORC1 activity in mice and its suppression of PI3K/Akt signaling.
Taken together, these data suggest the essentiality of PfI2 for the survival of blood stage parasites.
The essentiality of Hsf1 indicates that — besides being important for the response to carbon starvation as well as heat, osmotic, and oxidative stress — it also plays important functions in normal growth [ 3, 4, 76, 81].
The essentiality of these two nodes indicated by the ESM measure is supported by the fact that pro-inflammatory cytokines and inflammation are required for the resolution of infections [ 43].
Hence the set of conserved residues in conserved pockets in the set of EGs indicate a basis for the conservation of function and hence for the essentiality of that protein.
The essentiality of several point mutations in ssrA was tested in H. pylori.
However, the essentiality of this gene on glucose and glycerol minimal media indicates that vitamin B6 is in fact essential to E. coli, and should be included in the model biomass reaction.
Our results suggest that duplication age and genetic buffering determine the essentiality of mouse duplicates.
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