In summary, we have solved the structure of E. coli UppP at 2.0 Å resolution revealing an unexpected inverted topology repeat similar to many cross-membrane transporters and indicating the basis for phosphatase action deep within the mid-layer of a bacterial membrane.
The core of a GO annotation is comprised of a GO term representing a function, process or location, and an evidence code indicating the basis for the assignment, linked to a gene product and the reference for the observation.
These results indicate that the basis for the inability of strain to induce type I collagen and α-SMA mRNAs was likely to arise due to the relative inability of gingival fibroblasts to respond to TGFβ by inducing these mRNAs.
Genetic interaction analyses indicate that the basis for this sensitivity is different from the Rfa2 mutant lacking this domain.
It is more than merely getting a potential participant to sign or thumbprint a written document to indicate the legal basis for consent and for future reference [ 1- 3].
Given that doxorubicin, a commonly used anti-cancer drug, enhances nucleosome turnover, the identification of Chd1 in directing nucleosome turnover provides a mechanistic basis for its tumor suppressor role and may indicate the molecular basis for carcinogenesis in the absence of Chd1 (Huang et al., 2012; Liu et al., 2012; Yang et al., 2013).
Figure 3 illustrates the relationship between the initial compartments collected for microarray, indicating the basis upon which they were collected.
Identical length differences found between fragments following digestion with restriction enzymes indicated that the basis for the polymorphism was an insertion/deletion event.
This result indicates that the basis for divergent IL-6 induction by PGE2 in orbital fibroblasts concerns, at least in part, the cell-type specific interaction between pCREB and CBP following treatment with the prostanoid.
The reduced spastin expression in patient cells agrees with inferences from genetic analyses, which indicate that haploinsufficiency is the basis for pathogenesis of HSP in SPAST patients (Riano et al., 2009; Solowska et al., 2010).
