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These mutations indicate signalling sensitive positions and mark potential trigger points for receptor activation by agonists [ 11].
The increased activation of Notch-1, Stro-1, VCAM-1, and Sox-9 in OA cartilage could indicate signalling from a regenerative response in cartilage, and elucidating the signalling pathway could have bearing on the development of new diagnostic markers for diseased cartilage and the identification of potential new drug targets in the future.
Thus, the 2F1 and 2F1+2F2 components depend on synaptic transmitter release by the photoreceptors and so these components indicate signalling downstream of the sensory neurons.
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Arrows represent positive regulation, bars represent repression, and white bullets, together with the dashed lines, indicate signaling events.
The tyrosines present in their cytoplasmic regions may indicate signaling potential, although they were not found to be embedded in known consensus signaling motifs.
Importantly, MAPK-mediated CREB phosphorylation following a 60 mM K+ depolarization [36] was unaffected by this treatment (Figure 6B), indicating signaling downstream of CRFR1 was still intact.
Arrows indicate signal arising from carotid arteries (CA), heart (H), aorta (A) and bladder (B).
Only high values of r SD k) indicate signal energy from the steering direction.
Green arrows indicate metabolism-related proteins, pink arrows indicate signal transduction-related proteins, and blue arrows indicate transport-related proteins.
A value of matrix effect of 100% would indicate no matrix effect; lower values would indicate signal suppression and higher value signal enhancement.
Last is state 4, which is the finishing of handover, L2 receives LinkUp.ind to indicate signal strength going up and L3 message to inform of reaching network.
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