A number of proteins indicate interactions with an as yet unknown host, as indicated by the presence of predicted cell host remodeling enzymes, effector enzymes, hemolysin-like proteins, adhesins, NO reductase, and both type III and type VI secretory complexes.
Several gene families are present that indicate interactions with a eukaryotic host species, including response elements that potentially neutralize host defense molecules, in particular nitric oxide and other nitrogenous species.
Interestingly, 6d showed a reversible and non-competitive inhibitory action for acetylcholinesterase indicating interaction with the peripheral anionic site, whereas a reversible but competitive inhibitory action for butyrylcholinesterase.
However, expression of multiple genes often indicates interaction with a hub or a factor that interacts/associates with many other gene products.
The resonance frequencies of ghrelin, which are close to random coil values, were partially becoming better dispersed upon the addition of DPC, indicating interaction with this micelle-forming zwitterionic detergent.
Furthermore, high 4EBP1 protein levels predicted less benefit from the endocrine treatment tamoxifen, indicating interactions with hormone receptor signalling.
Kinetic profiles are usually consistent with hyperbolic mechanisms, indicating interactions with enzymes outside of the active site, possibly via allosteric mechanisms.
Edge colors indicate interaction reliability with darker edges denoting higher scores and greater reliability.
