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1Rank of pocket-centers within 4 Å of the considered ligand (brackets indicate hits exceeding the 4 Å criterion).
In (C ) and (D ), rounded rectangles indicate helix elements with colors matching helices in (E – F ), purple circles indicate hits corresponding to < 30 Å pairwise distance in the crystal structure, and pink circles indicate hits corresponding to > 30 Å pairwise distance in the crystal structure.
Rounded rectangles indicate helix elements, purple circles indicate hits corresponding to < 30 Å pairwise distance in the crystal structure, pink circles indicate hits corresponding to > 30 Å pairwise distance in the crystal structure, and black circles indicate MOHCA-gel 'spectator hits', which appear due to lack of rigorous background subtraction (Das et al., 2008 ; Kim et al., 2011 ).
The antifungal agent, ketoconazole, is known to bind to CYP126 in a typical azole heme type-II coordination mode by using heme absorbance shift assays (Kd=1.4 μ m; K. J. McLean et al., unpublished results), and ketoconazole was used here in displacement experiments to indicate hits that might bind within the CYP126 active site (displacement in CPMG only).
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Results of the 25 real-time feedback sessions are provided in Figure 7. Panels A C indicate hit rate, mean movement time, and mean endpoint error (measured as the difference between the formant space position at the end of the trial and the target formant position for that trial) as a function of block number, averaged across all 25 sessions.
Asterisk indicates hits only present in normalized GS-FLX reads.
The resulting psychometric curves indicated hit rates between 0.45 and 0.71 during presentation of the strongest stimulus change and false alarm rates between 0.29 and 0.43 during catch trials (with n = 49 316 trials per stimulus).
Three clouds of smoke appear during the incident that indicate shots hitting the pavement, according to officials.
3 The number of hits is followed by the number of mRNAs with this hit in brackets to indicate multiple hits.
He is a rare left-handed hitter whose career trends indicate he hits better against left-handers (.279 in 276 at-bats) than he does against right-handers (.254 in 1,027 at-bats).
cHighlighted rows indicate multiple hits of high sequence similarity, shared between the same gene pairs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com