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A number of observations indicate an instructive character of microRNA regulation in carcinogenesis.
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Stimulation of differentiation was found at a low dose (1 ng/ml) of IGF-I, clonal analysis indicating an instructive component of IGF-I signaling.
Restoring CTCF reinstates proper architecture on altered chromosomes, indicating a powerful instructive function for CTCF in chromatin folding.
Finally, it seems instructive to note that while individual risk perception does not always result in actual behaviour change, it may still indicate a readiness to change [ 31].
Our results indicate that instructive signals in the climbing fibers are not necessary for cerebellum-dependent learning.
These results indicate the necessity of an instructive biomaterial-based scaffold to direct stem cell differentiation, proliferation, paracrine activity as well as regulation of ECM deposition.
Together, our results indicate that Myc has an instructive role in damaged-induced ISC proliferation in regenerating Drosophila midguts as well as a permissive role in ISC proliferation during normal tissue homeostasis.
However, Wnt5a has been found to be required for stereocilia orientation in the cochlea, indicating that Wnt5a can play an instructive role in PCP during development [4].
The timing of expression, and the impact of knockdown on excitatory synapse formation, indicates that miR-132 coordinates an instructive transcriptional program that is necessary for the integration of newborn neurons into the adult central nervous system.
Our data indicate that Notch signalling, activated by JAG2, maintains pMN progenitors in an undifferentiated state but also provides an instructive signal that blocks the fate switch from MN to OLP.
There must be some way to indicate that Schurz's monument expresses contemporary sentiments that now seem badly out of date to use it as an instructive artifact of the mentality of the early twentieth century.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com