Together these results indicate a spectrum of anticonvulsant action for the KD in rats that includes threshold seizures induced via GABA receptors (BIC, PIC, GBL) but not those induced at glycine (strychnine) or the KA-subclass of glutamate receptors.
While this is a small exploratory study, the findings indicate a spectrum of views on CAM.
We searched for variability within each element that would indicate a spectrum of progress ranging from "proceeding well according to plan" (i.e. successful) to "addressing impediments and therefore lagging behind schedule" (i.e. challenged).
For four of five markers (with the exception of the marker ACOB), the rarefaction analyses and Chao1 diversity index both indicate a spectrum of rare alleles that remains to be sampled.
Indeed, as shown in ferret visual cortex, spiny stellate cells first develop as pyramidal neurons and subsequently lose their apical dendrites through developmental sculpting, indicating a spectrum of L4 morphological subtypes, with 'pyramidal' as the default or prototypical structure (Callaway and Borrell, 2011).
These data indicate that a spectrum of variability exists among the response classes, with responders being the most variable, relapsers being intermediate, and nonresponders being the least variable.
Our findings indicate that a spectrum of necrotic and inflammatory changes can be seen in peri-implant tissues of MoM arthroplasties and that these changes are most pronounced in cases of component loosening and pseudotumor formation.
The results of this study indicate a consistent spectrum of neoplastic and non-neoplastic effects produced by AN in the same rat strain, whether administered orally by bolus or by continuous dosing in the drinking water.
Even more importantly, the categories of sepsis, severe sepsis and septic shock should indicate a real spectrum of severity to be considered as different outcome categories [14].
These and other findings indicate a broad spectrum of cellular and molecular mechanisms that underlie the elevated morbidity and mortality associated with diabetic cardiomyopathy [ 1, 2].
The first mutation reports indicated a wide spectrum of loss-of-function mutations in PARK2 including simple mutations like nonsense, missense and splice site mutations, indels, as well as CNVs of the promoter region and single or multiple exons (Table 2) [ Hattori et al., 1998a, b; Kitada et al., 1998].
