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These and other reports (reviewed in [ 66]) seem to indicate a reactivation of the developmental mechanisms observed in FHF, in which Wnt inhibition is required for correct formation of the LV.
This may indicate a reactivation of the virus under local immunosuppression but none of the cases of CNS tumours (n=132) contained HCMV genomes and/or proteins in a significant proportion of tumour cells.
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In our patient, the low viral load of EBV and a negative test for heterophile antibodies (Clearview IM; Inverness Medical, UK) pointed against primary EBV infection and rather indicated a reactivation of latent EBV [ 19].
Pro-apoptotic markers, Bax, cleaved PARP, and cleaved caspase-3, all increased after treatment with MI-63 and may indicate a more comprehensive reactivation of p53.
The presence of detectable levels of IgM may indicate a recent HCMV reactivation, as IgM is the first antibody generated after infection or reinfection [ 28].
Follow-up ANOVAs indicated a significant reactivation × interference interaction for neutral, F 1,95) = 6.03, p<.02, η2 = 0.06, but not for positive or negative events, both F 1,95)<1.36, both p>.25, both η2<0.02.
The age cluster 24 27 Ma indicates however a reactivation of the manganiferous lateritic weathering late Oligocene.
Several studies indicate a weakening of cell-mediated immunity (CMI) and reactivation of latent herpes viruses during spaceflight.
Analyses of the influence of topography on orientation and magnitude of the maximum stress indicate a minimum overburden of about 500 m for regional reactivation to be valid.
Thus, high HPV prevalence in middle-aged women in Shanxi Province may indicate a relative lack of clearance or high frequency of reactivation of HPV infection.
While the precise mechanism of Rta-mediated KSHV reactivation is currently not resolved, results from comparative kinetics studies strongly indicate a casual role of Rta-induced G1 arrest in EBV and KSHV reactivations.
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