Sentence examples for indicate a negative role from inspiring English sources

These results indicate a negative role for miR-204 in the regulation of SIRT1 expression.

Together, these data indicate a negative role for LOXL2 in the expression and organization of tight junction complexes of basal-like carcinoma cells.

This indicated a negative role for L-type and R-type VGCC in calcium influx in the context of M. tuberculosis infection.

Significantly, our results on patient samples further indicate that these channels are expressed at high levels during active disease, indicating a negative role played by these VGCC during M. tuberculosis infection.

In particular, mounting evidence indicates a negative role for the p38alpha MAP Kinase in chemical-[7] and oncogene-[8] induced tumor formation and proliferation [9], in tumor cell directed cell polarity [10] [12] and in malignant invasion [11], [12].

Instead, the increased rate of P75+ progenitor proliferation found in the Gas1 mutant intestine indicates a negative role of Gas1, likely linked to suppressing Ret signaling.

Interestingly, all data indicating a negative role of STAT3 in disease progression were obtained with patients originating from Korea and Japan, whereas in European patients STAT3 activation appeared to be a beneficial parameter.

Previous studies [ 61– 64] have indicated a negative role for ANGPTL4 in other cancer types, and ANGPTL4 has previously been shown to be activated by HIF-1α [ 65] and to confer protection against hypoxia-induced apoptosis in cell lines.

In contrast, knockdown of NLRC5 was shown to increase cell surface expression of MHC class I in RAW 264.7 cells, which indicated a negative role of NLRC5 in regulating MHC class I expression [ 9].

These results indicate a negative regulatory role of HY5 in JA-mediated regulation of VSP2.

These observations strongly indicate a negative regulatory role of API5 in IAV-induced apoptosis, which is countered by NP-mediated repression of API5.