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These findings indicate a negative regulation of IL-8 release from neutrophils by Asm and ceramide.
Together, these results indicate a negative regulation of the PSR by AMPK.
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In addition to the directionality, the edges are also signed, with a positive sign indicating a positive regulation (activation) and a negative sign indicating a negative regulation (suppression).
Interestingly the GO analysis indicated a "negative" regulation of the immune system.
Mechanisms underpinning the association of HER-2 with ER-negative tumours need to be determined, with in vitro evidence indicating a negative regulation of HER2 transcription by steroid hormones [ 29].
Expression of miR-499 and Gadd45α were significantly increased at mRNA level whereas the expression of Gadd45α was robustly decreased at protein level in both diabetic heart and nucleus ambiguous, indicating a negative regulation of Gadd45α gene by miR-499.
The comparative analysis of the two classes of non-coding RNAs disclosed that 9 T-UCRs display their expression level that are inversely correlated with expression of 5 complementary microRNAs of the signature, indicating a negative regulation of T-UCRs by direct interaction with microRNAs.
Fold-change values less than one indicate a negative or down-regulation, and the fold-regulation is the negative inverse of the fold-change.
When an upstream promoter region (−2139 to −1172) was deleted, the promoter activity was found to elevate about 4-fold, indicating that a negative regulation element may exist in the region (Figure 2A).
These results indicate a negative role for miR-204 in the regulation of SIRT1 expression.
These results indicate a negative regulatory role of HY5 in JA-mediated regulation of VSP2.
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