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Numerous studies indicate a disruption of glutamate homeostasis in DR [ 133].
The symptoms complained of indicate a disruption of various physiological functions, including neurobehavioral, gastrointestinal and immunological.
These results indicate a disruption of the NAD+ salvage pathway in the hepatitis liver.
The pleiotropic tissue outgrowth defects in Prickle1 mutants indicate a disruption of PCP pathway that govern morphogenesis.
Collectively, these findings indicate a disruption of homeorhetic mechanisms that normally allow the dam to maintain homeostasis while simultaneously providing for growing fetuses and neonates.
Elevated GLCE levels in BPH (49% of the patients) and prostate cancer (21% of the patients) could indicate a disruption of the restricting mechanism(s) and a specific type of GLCE expression disorganization in this pathology, while a decrease in GLCE expression may be associated with specific prostate cancer subtypes.
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The proliferation indices for these lesions showed modest increases over normal epithelium, and positive p53 staining was evident in 4 of 10 cases, indicating a disruption of the keratinocyte cell cycle in these lesions.
The rise in plasma and liver tissue extract concentrations of choline and phosphocholine, together with decreased lipids and lipoproteins, after SWCNTs treatment indicated a disruption of membrane fluidity caused by lipid peroxidation.
In addition, immunostaining of Hes1 on back skin sections revealed a loss of staining in Rbpj/Tgfb3-Cre hair follicles at P8, indicating a disruption of Notch signaling in the follicular lineages (Figure 3E).
The molecular phenotype of the Tbx6 mutant embryos indicates a disruption of nodal signaling and is similar to the phenotype of embryos with decreased levels of Nodal expression around the node [26].
For example, in the case of Ste4p, the protein is uniformly distributed on the cell membrane in these strains (Figure 4A) indicating a disruption of the polarizing positive feedback mechanisms.
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