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These results indicate a defect of mature moDC after activation by TLR7/8 ligand.
The RNAi experiments found to produce the Elm extra pseudovulvae phenotype were further scrutinized for ectopic VPC divisions during larval development, which would indicate a defect of cell-cycle quiescence (Hong et al. 1998).
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However, these markers were undetectable in DU145 cells upon autophagic stimulation, indicating a defect of autophagy in this cell line.
A lack of sensation of the lips, cheek, forehead and cornea in some patients indicated a defect of the sensory root of the trigeminal nerve [ 20].
Instead, accumulation of light chain 3, microtubule-associated protein (LC3-I) was observed in cells undergoing PDT, PDT+EGF-SubA, or treatment with chloroquine, indicating a defect of autophagy in these cells (Supplementary Figure 9A).
Moreover, in vivo experiments indicate a defect in clearance of wild-type neutrophils in the bone marrow of AnxA1−/− mice.
The underlying assumption then is that slower response times indicate a defect in one of the discrete processing operations that additively determine the duration of the response process.
All these phenotypes might indicate a defect in repair of DSBs resulting from intrinsic sources such as DNA replication.
We did so in order to determine whether the absence of hybridization signals for some microarray spots was due to the absence of any DNA there, which would indicate a defect in the manufacturing of the microarray at those spots.
This metabolic state has been termed "selective insulin resistance" to indicate a defect in one arm of the insulin-signaling cascade, potentially downstream of Akt.
These results indicate a defect in the migration of renal embryonic endothelial cells that may cause defective glomerulogenesis (Fig. 3A).
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