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The majority of the studies indicate a central role for the endothelium [16, 34, 35].
These studies also indicate a central role of CD4+ T cells in CD pathogenesis and point to B cells as important players, which is in accordance with the key steps highlighted by the immunological models of pathogenesis.
There is compelling evidence to indicate a central role of Toll-like receptors (TLRs) in the stimulation of innate and adaptive immunity when applied at the site of immune responses [1] [3].
However, even if collectively these data indicate a central role of TrkB and Ret receptors in RA-induced cell differentiation, a clear understanding of their respective biological need is still lacking and the mechanism for their involvement in this process has been never clarified.
Furthermore, recent studies are beginning to indicate a central role of the collagen framework in the maintenance of cartilage cells.
Several investigations in experimental animal models already indicate a central role of CD18 integrins in SpA-like disease [ 14- 16, 37].
Similar(47)
Fronto-parietal coherence predicted the accuracy of subsequent imitation, indicating a central role for these structures in imitation learning.
A recent study by Walecka and co-workers revealed that a higher percentage of invasive E. faecalis isolates produce lipases compared to non-invasive isolates [75], indicating a central role for lipase activity during invasive infection.
Furthermore, studies by Fristrom and Fristrom [21] demonstrated that the elongation and eversion of the leg imaginal discs could be reversibly inhibited by cytochalasin B, indicating a central role for the actin cytoskeleton in driving leg disc morphogenesis.
These studies indicated a central role of cancer proteins within the interactome.
This result indicates a central role of the pre-SMA within a distributed frontal-prefrontal network for voluntary action.
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CEO of Professional Science Editing for Scientists @ prosciediting.com