The index trial was the first clinical exposure in 81% of the participants, while the rest had participated in at least one trial apart from the current trial.
The Pearson rank correlation was 0.90. Figure 2 is a scatter plot of the results (excluding those meta-analyses that had only a single trial, which would all lie along the diagonal), subgrouped by whether the index trial was more or less than 50% of the weight in the meta-analysis, irrespective of the absolute size of the trial.
Because the method of disease ascertainment differs depending on the outcome of the index test, the trial is subject to differential verification bias [ 9].
This trial is indexed in the German Clinical Trials Register (DRKS-ID: DRKS00007931).
The primary outcome measure of the SoLID trial is LV mass index (LVMI), and the primary endpoint is LVMI at 12months.
Time to complete each trial is recorded, and an interference index by subtracting trial C from CW.
The CI for the treatment effects were within 10 points on the Oswestry disability index that the trial was designed to detect.
We plan to do this once the pre-defined protocol for the first 140 men treated in the 'INDEX' trial is complete.
The UK Clinical Research Network, launched in February 2005, has training as an important part of its remit (www.ukcrn.org.uk/index/training). 6 A 'clinical trial' is specifically defined by the EU Directive as any investigation in human subjects intended: To discover or verify the clinical, pharmacological or other pharmacodynamic effects of one or more medicinal products.
The lipid abnormalities are not necessarily an adverse event because the atherogenic index in the CHARISMA trial was essentially unchanged.
28 The unadjusted intracluster correlation coefficient for Barthel index scores in this trial was 0.36 at baseline; however, for the change in scores from baseline to three months, allowing for the effect of treatment, trial administrative centre, and type of care home, it decreased to 0.09 (table 3).
