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Logistic regression analysis showed that women with insomnia disorder as defined by an insomnia severity index total score ≥8 had 2.2-fold increased risk of reporting recurrent headache, 3.2-fold increased risk of migraine, and 2.3-fold increased risk of TTH, after adjusting for anxiety and depression.
RDQ = Roland Disability Questionnaire; PRI-T = Pain Rating Index Total score; BDI = Beck Depression Inventory.
aAdjusted for recruitment site, sex, age, income and Western Ontario McMaster Index total score.
In a 3-year, randomized double-blind study, a treatment with glucosamine sulfate produced a reduction of about 20% in the Lequesne´s index total score [ 28].
Given that our primary outcome of shoulder pain and disability index total score includes both the pain and function subscales, the benefits of active treatment on function could have been masked at the 11 week time point and attenuated at the 22 week time point, when a significant treatment group effect was found for shoulder pain and disability index total score.
The active group showed a significantly greater improvement in shoulder pain and disability index total score at 22 weeks than did the placebo group (mean between group difference 7.1, 0.3 to 13.9) (table 3, fig 2).
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Responses to each item was scored from 0= not at all to 3 = severe and were summed to create a withdrawal severity index (total scores could range from 18 to 60).
Similarly, there were no significant group effects for changes in the Insomnia Severity Index (ISI) (p = 0.44) or the Pittsburgh Sleep Quality Index (PSQI) total score (p = 0.79).
The resulting indices were then combined to obtain the global performance index (total PHC score).
The primary endpoint is the NPI index (total summary score reflecting frequency by severity) at 4-months.
The prognostic index (total possible score = 5) developed according to the above rules (Table 2) adequately predicted mortality in the development and validation cohorts; mortality increased with increasing scores of the proposed index.
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