All indices of tolerability were defined prior to enrollment of the first subject, and the analytic plan was stipulated in advance.
Instead, it may be necessary to observe the rate of resolution of the acute toxicity and use this as an index of safety and tolerability (Harrington et al, 2009 ).
CT-2103 (Xyotax™) is a polymer drug conjugate designed to improve upon the therapeutic index and tolerability of conventional taxanes.
In an attempt to improve the therapeutic index of 5-FU and its tolerability, research has focused on the study of oral 5-FU prodrugs.
The issues of tolerability and especially the risk of tardive dyskinesia are not addressed in an 18-month study with a 75percentt dropout rate.
"Also there may be issues of tolerability of the patch in some people.
Analysis of tolerability was carried out in 123 patients.
Two give-a-shits strains the threshold of tolerability.
Interpretation of tolerability correlations was therefore limited.
The PEG-only group was better in terms of tolerability.
