34 37 This re-evaluation will only be conducted on reviews included in the finally hierarchical index of interventions.
Produce a hierarchical index of interventions that have been shown to significantly (p<0.05 and a 95% CI that does not include the null value) reduce unscheduled admissions using estimates of the absolute risk difference and the quality of the evidence.
The recent experiences gained in the development of drugs as cancer chemopreventive agents lead to the conclusion that the therapeutic index of proposed interventions should be titrated to relative risk of transformation.
Apart from the type of responsiveness index, other factors affect the size of the responsiveness index such as type of intervention, patient population under study, and timing of data collection [ 17, 21, 22].
This therapeutic approach was borne out of realisation that virus factors, although conceptually attractive targets because they should, in theory, provide a wide therapeutic index, are challenging points of intervention because of the high mutability of their genomes.
Today, most common pathogens are resistant to common antibiotics [ 16] with the need for a high index of suspicion, prompt operative intervention, appropriate antibiotic treatment and proper resuscitation [ 5].
Significant variables included in the bivariate analysis (i.e., age, sex, aneurysm location, bicaudate index, Fisher scale, and type of intervention).
Therefore, we suggest that maintaining a high index of suspicion and timely intervention is the key to better outcome in the patients.
In trauma patients, airway obstruction may result in acute respiratory de-compensation, so a high index of suspicion and rapid intervention are required.
Second, due to sample size restrictions in the ecological analyses, we could not model each indicator of MCNH interventions separately in a multivariable model, and instead we chose the CCI which is a composite index of eight different key interventions.
