Results: Among all study participants, Mexican American women with PCOS had significantly higher mean values for body mass index, fasting insulin, and HOMA but lower mean fasting glucose/insulin levels than white women.
Overall, bariatric surgery resulted in significant reduction of body mass index, fasting plasma glucose, fasting plasma insulin, and normalization of glycosylated hemoglobin levels.
Multivariable analyses were adjusted for differences in baseline cardiovascular disease risk factors (body mass index, fasting insulin, glucose and lipids, smoking, physical activity, childhood and adulthood social class) to determine whether these explained any differences in survival between the groups.
We also examined the relationship between body mass index, fasting serum insulin and DM.
BMI (Body Mass Index), fasting blood glucose (FBG) and HbA1C were determined.
Homeostasis model assessment of insulin resistance index (fasting plasma insulin [mUI/L] × fasting plasma glucose [mg/dL])/405) (Supplementary Materials) and Quicky index {1/log(fasting plasma insulin [mUI/L] + fasting plasma glucose [mg/dL])} (Supplementary Materials) monitored insulin resistance evolution.
Finally, the homeostasis model assessment (HOMA) insulin resistance (IR) index (fasting plasma insulin [μU/mL] × fasting plasma glucose [mg/dL]/405) was also recorded in each patient.
Current guidelines recommend the regular monitoring of metabolic risk in people treated with antipsychotic medication, such as fasting glucose, body mass index, fasting triglycerides, fasting cholesterol, girth, high-density/low-density lipoprotein, blood pressure and symptoms of diabetes.
However, taking into account fasting hyperinsulinaemia in patients with NASH, the calculated adipose IR index (fasting NEFA × fasting insulin 31) was significantly elevated (64.4 ± 9.1 vs. 20.5 ± 3.9 mmol/l pmol/l; p = 0.0002) in patients with NASH.
The results point to an age-independent positive association between GIT glycosidase activity and the body mass index, fasting blood glucose and insulin resistance (r ≥ 0.95).
