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Table 3 focuses on the association between the index dose and total direct medical costs.
The total number of palivizumab doses received during the RSV season was recorded for each subject along with the calendar month of the index dose and the average and maximum number of days between each dose received.
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RSV-related hospitalizations were identified using ICD-9-CM diagnosis codes and examined over 2 observation periods: post-index dose and RSV season.
Chemotherapy dose determined the HEC/MEC status of certain chemotherapy drugs (eg, cyclophosphamide and cisplatin) by calculating the index dose administered and then applying the National Comprehensive Cancer Network® (NCCN® -recommended GuideliNCCN® -recommendedhe time of the study for classification (Table S3).
The highest mean daily dose over a 90-day period was defined as the "index dose range" and was calculated based upon the quantity of insulin received over a 90-day period and the number of days of insulin covered under prescription.
Multiple regression analysis adjusted for age, sex, body mass index, dose of antidepressant, and depression severity showed that TCI Self-Directedness (SD) scores were negatively associated with serum BDNF levels (β = −0.23, p = 0.026).
14– 18 For example, a lung cancer patient on cisplatin (index dose of 100 mg/m) and vinorelbine would be assumed to have initiated a therapy involving four treatment cycles with an allowed rest period of 4 weeks between each cycle.
Furthermore, a U-shaped pattern for average, all-cause costs (except drug costs), diabetes-related inpatient costs, and resource use were also generally observed, with costs highest among those who received the lowest and highest index dose ranges.
Resource utilization generally followed the same pattern as costs, with number of office visits increasing as the dose increased and the highest hospital length of stay, number of hospitalizations, number of emergency room visits, and number of diabetes-related hospitalizations were generally highest among those in the lowest and highest index dose cohorts.
Subjects were deemed compliant if they received ≥5 doses of palivizumab with no gaps (>35 days) between doses, and they received their index dose by November 30.
Table 2 reveals antidiabetic medication use, based upon index dose, both at the index date and during the pre-period.
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