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We looked at 26 index cases and 280 people that they had close contact with.
Index cases can play a critical role in understanding an outbreak's origins.
Index cases and controls were matched by the time of the hypoglycemic event.
Medical co-morbidities were not common in index cases.
As noted above, these strategies correspond to either treating index cases and all first-degree contacts, or treating index cases only.
Three hundred and ninety eight participants finished the study, of whom 166 were index cases and 232 were siblings of index cases.
Is it necessary to treat all first-degree contacts of index cases?
Of 433 index cases recruited, 366 had HHCs that met inclusion criteria.
HL index cases were recruited from three haematology units in the Paris area.
Three 1st degree relatives of index cases with non-synonymous DNA changes were studied in addition.
Neither could we exclude the possibility of contemporaneous index cases in large households.
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