Patients without pathologic staging were classified as indeterminate stage unless there was clinical evidence of distant metastases at diagnosis.
If pathologic staging was not available, cases were classified as indeterminate stage unless there was clinical evidence of distant metastases at the time of diagnosis.
Thirty-seven (84.1%) of 44 eligible patients, predominantly female, middle-aged, Bolivians at the indeterminate stage, were enrolled.
Thus in patients grouped as being in the indeterminate stage, a statistically significant decrease in reactivity against KMP11 was only observed 6 months post-treatment.
In absence of treatment, the acute phase is followed by an indeterminate stage in which the parasites are present into specific tissues [ 7].
Treatment of young women at the chronic, indeterminate stage of infection is likely to lower their risk for developing cardiac complications (9 ).
Development of new drugs for Chagas disease is fraught with difficulty, not least because patients entering the indeterminate stage are asymptomatic and the difficulty to detect parasites then and in early chronic infections complicates any definitive assessment of cure.
The reactivity of the sera from 46 adult Chronic Chagas disease patients living in a non-endemic country without vector transmission of T. cruzi (15 patients in the indeterminate stage, 16 in the cardiomiopathy stage and 16 in the digestive stage) and 22 control sera from non-infected subjects was analyzed.
However, only 30% of infected individuals during the indeterminate stage develop later heart or digestive tissue damage, suggesting an early infection control which may be related to the immune system and also to the parasite's strain and the host's genetic factors [ 8, 26].
For pancreatic cancer, [18F]FDG has been useful in the evaluation of indeterminate pancreatic masses, staging of pancreatic carcinoma, detection of metastatic disease and differentiation of viable tumours from post-therapeutic processes like necrosis or scar tissue [4, 5].
