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The low background signals allowed resolution of samples previously shown to have indeterminate results for anti-HIV antibody in the AxSYM assay.
The proportion of indeterminate results for both IGRA was higher in children younger than three years of age compared to those older than three years of age.
This study had a much lower rate of indeterminate results for QFT-IT (n = 1, 1%) than other studies [7], [16], [17], [18], which may also be related to processing issues [15].
Median antigen dependent and mitogen induced IFN-γ production for QFT-IT positive, negative and indeterminate results for HIV-negative and HIV-positive patients respectively are depicted in figure 1.
Although there were more indeterminate results with the T-SPOT.TB assay than with the QFT-IT assay overall (14/96 vs. 3/96, p = 0.009), the majority of indeterminate results for the T-SPOT.TB assay were attributable to potential laboratory error (Tables 2 and 3).
No endocervical samples gave indeterminate results for gonorrhoea.
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That may be advanced when evaluate sensitivity and diagnostic yield in patients with an indeterminate result for GERD after 48-h or 24-h pH monitoring [ 17, 18].
When IHC yielded an indeterminate result for HER2 (2+) or when a discordant result between primary tumor and metastasis was observed, FISH was carried out using HER2 FISH PharmDx® kit (Dako Denmark A/S) and results were interpreted according to manufacturer's instructions [ 8].
They reported that inability to achieve the target heart rate is the main reason for an indeterminate result of TWA testing.
Three months after enrollment, we asked study participants who had had a negative or indeterminate result from a blood test for schistosome antibodies at the time of enrollment to complete an Internet-based questionnaire about freshwater exposures, health symptoms, and medical tests or treatments for schistosomiasis since enrollment.
When the indeterminate results were excluded for sensitivity calculation, QFT-IT and IP-10 yielded the diagnostic sensitivities of 90.6% (95%CI: 86.3%–94.9%) and 92.5% (95%CI: 88.6%–96.4%) respectively (Table 2).
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