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InterVA-4 generates up to three probable causes of death for each case with their assigned likelihoods or indeterminate result.
In all discrepant cases, E-test and CDT gave an indeterminate result and 'non-ESBL' phenotype, respectively.
In most cases of a negative or indeterminate result, documentation of EU exam results is limited to a written note in the patient chart.
Of these, 604 (19%) were not offered HIV testing, 465 (18%) refused testing, 379 (15%) were HIV seropositive, 29 (0.8%) were tested but results were not reported, and 1 (0.03%) had an indeterminate result.
When asked regarding the frequency of 'indeterminate' results (always, sometimes, or never), the majority (76%) voted for 'sometimes.' When asked, 'In what categories did they see an indeterminate result,' the most common answer (86%) was 'not sure'.
For the two cases of disagreement, OIC-HIV gave an indeterminate result whereas the WB was positive using CDC criteria [13].
23 patients (14%) had an indeterminate result and this proportion decreased with increasing CD4 cell count in HIV-positive patients (test for trend p = 0.03).
Factors associated with an indeterminate result were: CD4 cell count below 300 cells/µl (by both univariate and multivariate analysis), age above 33 years (by univariate analysis only) and male sex (by multivariate analysis only).
Also, when excluding indeterminate result, we found no difference in sensitivity between HIV-negative and HIV positive patients and no difference in median level of antigen dependent IFN-γ production.
'IND' indicates indeterminate result.
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Fewer pregnant women than non-pregnant persons had a positive Western blot result within one month of their indeterminate result [(0/39 (0%) vs. 13/34 (38.2%), p<0.01].
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