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Here, we used a ribonucleoprotein-based CRISPR/Cas9 system to model human clonal hematopoiesis of indeterminate potential and acute myeloid leukemia (AML).
Overall, these data suggest that NPM1 mutations are a secondary or late event in the pathogenesis of AML and are preceded by founder mutations in genes that may be associated with recently described preclinical states such as clonal hematopoiesis of indeterminate potential or clonal cytopenias of undetermined significance.
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However, in either set of circumstances, upon inception, that initial aneuploid cell is a differing self-referential entity with its own distinct and indeterminate potentials.
This supports the use of the term "melanocytic neoplasm of indeterminate biologic potential" for tumours that demonstrate intermediate histological features and might have an aggressive clinical behavior [ 36].
On occasions it is recommended to classify the tumour as an "atypical adrenocortical neoplasm" or "adrenocortical neoplasm of indeterminate malignant potential".
This is why he conceives of the infinite as pertaining to material explanation, as it is indeterminate and involves potential cutting or joining (cf. Section 7.5).
However, recent information on the performance of the QFT test in immuno-compromised individuals demonstrates that only severe immune-suppression with low CD4 counts may lead to indeterminate results and potential false negative results in case of no positive mitogen control [ 37- 40].
Despite the potential for indeterminate results using the Novagnost assay, we found the test of practical use, especially considering the time-saving convenience of its ready-to-use reagents and their long stability.
The potential of indeterminate results has led many to question the utility of CNV analysis in prenatal diagnosis [ 143] and has raised concerns on the possible emotional harm on the expectant parents [ 144].
When assessing an indeterminate nodule for possible malignant potential, the first rule of thumb is to look for comparison examinations.
Overall, we conclude that the results from the nested case-control study are indeterminate with regard to the potential lung carcinogenic effects of REC from TDE in this mining environment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com