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Hotspots have also been observed in other independent contexts, e.g., HIV integration sites [ 13], chromosomal breakages in various cancers [ 14, 15] and other diseases [ 16].
Furthermore, a putative domain must be found to occur in at least two different independent contexts ie with different domain partners.
Taken together, although it is probable that NDE1 and NDEL1 interact with DISC1 in independent contexts, we propose an alternative notion that both NDE1 and NDEL1 can simultaneously associate with DISC1 at certain but key developmental time points.
IgG-mediated MC degranulation has not been studied in as great detail as IgE-dependent degresponsesn responses, but both contribute to vascular pathology in independent contexts, such as the Arthus reaction and anaphylaxis (Vaz and Ovary, 1968; Hazenbos et al., 1996; Sylvestre and Ravetch, 1996).
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CEO Narayan Babu tells me that these are independent, context-aware apps – they are separately installed but are able to use the information that Friday tracks.
However, this argument must be interpreted with caution, as size and age as independent context variables are hardly immune to confounding.
f l c l = 1 L f also resulted from an independent context clustering algorithm that is a fast and simplified version of contextual additive structure [19].
Rev. 98, 708 729) called the interactive context (which affects the meaning, or the interpretation, of the target event) in contrast to the independent context (which does not interfere with the meaning-based interpretation of the target event).
MacFarlane's framework is relativist, with the idea that the truth of a sentence, as well as the evaluation of an assertion, for some particular kinds of sentences (e.g., concerning future contingents) must be judged with respect to both the original context of use, and a separate independent context of assessment (e.g., by an assessor at a future time).
The critical question is this: does one narrowly partition out individual causes, in this instance one disease causing pathogen or another, and address them as independent context free problems amenable to context free solutions?
This shows that a skill measured in one context (OSCE) appears to be relevant in a clinical examination in a different independent context (OSLER clinical examinations), giving some indication of construct validity for the empathy measure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com