Sometimes even a doctor at a hospital may not know where the drug originated, and whether the institution purchased a commercially available drug from an independent compounding pharmacy rather than a manufacturer, said Dr. Michael Carome, deputy director of the health research at the watchdog group Public Citizen.
Using datasets of netilmicin, vancomycin, tobramycin, and gentamicin in neonates, it was confirmed that the performance of the amikacin GFR model was similar to the independent, compound-specific models [ 125].
It becomes difficult to compare a condition that has a unique test/technology that tests only for the condition of interest to a technology that can detect many conditions, some of which are related through their differential diagnosis, while others involve independent compounds in the MS/MS profile.
Thus, the performance of the transcriptomic approach is apparently independent of compound chemical structures, and this property has practical importance for predicting the targets of compounds that have novel chemical structures.
For purposes of inter-compound comparisons of the slope terms, it is convenient to work with rescaled values β'j which are independent of compound abundance (see Methods).
Similar ratios can also be detected in the Prous Drugs of the Future subset as an independent development compound source i.e. with a 75% overlap with GVKBIO papers but 37% for patents.
Strain averages for volumes of 35 independent and compound regions were entered into GeneNetwork (GN) (www.genenetwork.org).org
Importantly, these effects were independent of compound type.
The ability to discern between independent and compound mutations is a major advantage of this assay.
In addition, sensitivity analyses were conducted for autoregressive, independent and compound symmetry, and the results remained robust.
Standard Sanger sequencing methods routinely used in diagnostic laboratories are unable to distinguish between independent or compound mutations.
