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The alpha emitter 211At is proposed in radionuclide therapy because of the optimal linear energy transfer (LET), high RBE value and independence of dose rate and oxygen level [1, 2].
Because of their nonlinearity of dose [ 77], omeprazole and lansoprazole do not afford this same independence of dose.
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It assumes the distribution of mortality-corrected time to tumor is lognormal with the nth power of time inversely proportional to dose and with dose independence of the variability of the logarithm of time to tumor.
The ranges 0.8 θH−1.25 θH and 0.7 θH−1.43 θH were used as the criteria for dose independence of AUC and C2min over the entire range of doses administered in this study, respectively.
The models, however, do rely on few assumptions that allow for dealing with the confounding factors, which include the stability of PK/PD relationships over time and upon multiple dose administration, the similarity of subject pools in factors other than the confounding ones, and the dose independence of CYP2D6 effect on clearance.
The dose independence of strain-hardening behavior suggests that radiation-induced defects and deformation-produced dislocations give similar net strain-hardening effects.
It is attempted to explain the dose independence of the plastic instability stress by a straightforward shifting of tensile curves by the appropriate strain corresponding to the radiation-induced increase in yield stress.
Epidemiological data suggest that circulatory disease risk is significantly elevated only for acute or cumulative doses of about 0.5 Gy and above; nonetheless, the dose rate independence of risk remains (AGIR 2010).
A forward selection multivariate linear regression model was constructed to evaluate the independence of salbutamol (high or low dose) against days alive and free of ALI.
All cell lines showed significant sensitivity to DRB (p < 0.05 with the test of independence) at doses above 40 μM, compared to untreated cells.
We utilized a delta score to quantify the deviation from the expectation of zero interaction, and proved that a delta score value of zero implies both probabilistic independence and dose additivity.
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