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In this spirit, the universe is seen as being in a constant process of re-creating itself, as everything that exists is a mere aspect of qi, which, "condensed, becomes life; diluted, it is indefinite potential".
They have an indefinite potential for self-renewal and are hypothesised to drive tumourigenesis [ 79].
Worry involves rather indefinite potential future dangers so that such attempts usually fail, because no satisfactory resolution exists.
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Telomeres shorten at each round of cell division and cellular mechanisms that counteract this loss confer indefinite proliferation potential characteristic of cancerous cells [2].
Embryonic stem (ES) cells, with their indefinite replication potential, pluripotency, and genetic flexibility, have attracted great interest, and methods for inducing their neural differentiation have been extensively studied [6].
These rare CSCs have indefinite proliferative potential and are believed to be responsible for tumor invasiveness and heterogeneity.
Taken together, we have generated a non-tumorigenic progenitor population capable of nearly indefinite expansion potential with a mesodermal phenotype.
Molecular studies of bladder tumors have identified several genetic alterations including self insufficiency in growth signals, evasion of apoptosis, sustained angiogenesis, acquisition of indefinite replication potential and metastasis.
Both concepts consider that tumors originate from single cells that have acquired multiple molecular alterations, have developed indefinite proliferative potential, and assume that (micro environmental cues have an impact on the composition of a cancer.
Telomerase confers indefinite proliferative potential to in vitro cultured cells by virtue of its ability to elongate chromosome ends, thus preventing critical telomere erosion associated with cell division and the activation of a persistent DNA damage response (Bodnar et al, 1998).
Thus, although the cell-of-origin may not be identified for all types of leukemia yet, these cells have to exhibit the essential stem cell characteristics of self-renewal and indefinite proliferative potential to give rise to LSCs that initiate and maintain the disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com