Sentence examples for indeed upstream from inspiring English sources
No changes in phospho-Src416 and total Src protein levels were observed when K-ras was silenced (Fig. 3C), indicating that Src is indeed upstream of K-ras in this hypoxic signaling pathway.
If mTORC2 is indeed upstream of mTORC1, it might be only under specific conditions or only with regard to particular mTORC1 substrates (other than S6K1), as we and others failed to detect an effect of mTORC2 disruption on S6K1 phosphorylation [14], [15].
Indeed, upstream DNA in an initiation complex would pass near the location of the Tfg2 WH domain on the protrusion (Chen and Hahn, 2004).
We found that BH4-Bcl-2 and BH4-Bcl-Xl did not protect against PAC-1-induced cell death, confirming that the target of these peptides is indeed upstream of caspase-3.
Inhibiting PEA3 may also allow for a larger therapeutic window for GSI treatment, enabling the reduction of pharmacological doses or possibly eliminating the need for the GSI if PEA3 is indeed upstream of Notch signaling, thus lowering resultant undesirable side effects such as gastrointestinal toxicity and possibly skin cancer.
Authors' response: We agree that indeed the upstream genes that belong to the family of RtcB-like proteins may hold the secret of RFH function.
Single-cell expression analyses during in vitro cellular reprogramming have confirmed that Sall4 is indeed an upstream activator of Oct4 expression [ 69].
Targets of p53 are, indeed, both upstream regulators of autophagy (e.g,. PTEN, TSC2, β1, β2 and γ subunits of AMPK) and proteins directly involved in autophagosome formation (e.g., ULK1, UVRAG, ATG2, 4, 7, 10).
Gpr1 indeed functions upstream of Tps2 as reflected in the gene expression profile of the tps2Δ gpr1Δ double mutant, which is most similar to the tps2Δ profile and the inverse of the gpr1Δ profile.
Indeed, the upstream edge of the post-translocated 4-nt transcript fits snugly between the RNAP active site and the distal tip of the σ3.2-loop, which contacts the upstream RNA DNA bp at −3, and the t-strand bases at −4 and −5.
Indeed, genes with upstream CNSs overlap significantly with H3K27me3-marked genes.
